PREVALENCE AND PATTERN OF PEPTIC ULCER DISEASE AMONG PATIENTS UNDERGOING UPPER GASTROINTESTINAL ENDOSCOPY IN KOSHI HOSPITAL: A CROSS-SECTIONAL DESCRIPTIVE STUDY

Background: Acid peptic disease is one of the most common diseases encountered in outpatient department.There has been limited study on prevalence of different types of peptic diseases among patients undergoing upper gastrointestinal endoscopy especially in eastern part of Nepal.The aim of this study was to find out prevalence of different types of

Abstract The tumor microenvironment (TME) is essential for immune escape by tumor cells.It plays essential roles in tumor development and metastasis.The clinical outcomes of tumors are often closely related to individual differences in the patient TME.Therefore, reprogramming TME cells and their intercellular communication is an attractive and prom

The metabolic response to endotoxemia closely mimics those seen in sepsis.Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in vivo, and in human septic patients.We further show that HERBATINT 3N enhanced activation of the enzymes responsi

Adolescence is of particular significance to schizophrenia, since psychosis onset typically occurs in this critical period.Based on the N-methyl-D-aspartate (NMDA) receptor hypofunction hypothesis of schizophrenia, in this study, we investigated whether and how repeated NMDA receptor blockade during adolescence would affect GABAergic interneurons i